The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest

The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest

Summary: mTOR is a serine/threonine kinase and a master regulator of cell growth and proliferation. Raptor, a scaffolding protein that recruits substrates to mTOR complex 1 (mTORC1), is known to be phosphorylated during mitosis, but the significance of this phosphorylation remains largely unknown. H...

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Bibliographic Details
Main Authors: Mohamed Moustafa-Kamal, Thomas J. Kucharski, Wissal El-Assaad, Yazan M. Abbas, Valentina Gandin, Bhushan Nagar, Jerry Pelletier, Ivan Topisirovic, Jose G. Teodoro
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Cell Reports
Subjects:
mTORC1
raptor
S6K
PDCD4
eIF4A
cell cycle
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720312195

Internet

http://www.sciencedirect.com/science/article/pii/S2211124720312195

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