Dynamic Effects of Topoisomerase I Inhibition on R-Loops and Short Transcripts at Active Promoters.

Dynamic Effects of Topoisomerase I Inhibition on R-Loops and Short Transcripts at Active Promoters.

Topoisomerase I-DNA-cleavage complexes (Top1cc) stabilized by camptothecin (CPT) have specific effects at transcriptional levels. We recently reported that Top1cc increase antisense transcript (aRNAs) levels at divergent CpG-island promoters and, transiently, DNA/RNA hybrids (R-loop) in nuclear and...

Full description

Bibliographic Details
Main Authors: Jessica Marinello, Stefania Bertoncini, Iris Aloisi, Agnese Cristini, Guidantonio Malagoli Tagliazucchi, Mattia Forcato, Olivier Sordet, Giovanni Capranico
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4718701?pdf=render

Internet

http://europepmc.org/articles/PMC4718701?pdf=render

Similar Items