Inhibiting spinal neuron-astrocytic activation correlates with synergistic analgesia of dexmedetomidine and ropivacaine.

Inhibiting spinal neuron-astrocytic activation correlates with synergistic analgesia of dexmedetomidine and ropivacaine.

BACKGROUND: This study aims to identify that intrathecal (i.t.) injection of dexmedetomidine (Dex) and ropivacaine (Ropi) induces synergistic analgesia on chronic inflammatory pain and is accompanied with corresponding "neuron-astrocytic" alterations. METHODS: Male, adult Sprague-Dawley ra...

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Bibliographic Details
Main Authors: Huang-Hui Wu, Jun-Bin Yin, Ting Zhang, Yuan-Yuan Cui, Yu-Lin Dong, Guo-Zhong Chen, Wen Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3962412?pdf=render

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http://europepmc.org/articles/PMC3962412?pdf=render

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