Discovery of novel L-type voltage-gated calcium channel blockers and application for the prevention of inflammation and angiogenesis

Discovery of novel L-type voltage-gated calcium channel blockers and application for the prevention of inflammation and angiogenesis

Abstract Background The ways in which microglia activate and promote neovascularization (NV) are not fully understood. Recent in vivo evidence supports the theory that calcium is required for the transition of microglia from a surveillance state to an active one. The objectives of this study were to...

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Bibliographic Details
Main Authors: Madhu Sudhana Saddala, Anton Lennikov, Anthony Mukwaya, Yan Yang, Michael A. Hill, Neil Lagali, Hu Huang
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Journal of Neuroinflammation
Subjects:
Angiogenesis
Calcium
Inflammation
L-VGCC
Microglia
Neovascularization
Online Access:http://link.springer.com/article/10.1186/s12974-020-01801-9

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http://link.springer.com/article/10.1186/s12974-020-01801-9

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