Topoisomerase inhibitors promote cancer cell motility via ROS-mediated activation of JAK2-STAT1-CXCL1 pathway

Topoisomerase inhibitors promote cancer cell motility via ROS-mediated activation of JAK2-STAT1-CXCL1 pathway

Abstract Background Topoisomerase inhibitors (TI) can inhibit cell proliferation by preventing DNA replication, stimulating DNA damage and inducing cell cycle arrest. Although these agents have been commonly used in the chemotherapy for the anti-proliferative effect, their impacts on the metastasis...

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Bibliographic Details
Main Authors: Jiafei Liu, Like Qu, Lin Meng, Chengchao Shou
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Topoisomerase inhibitors
Motility
CXCL1
JAK2-STAT1
Reactive oxygen species
PTP1B
Online Access:http://link.springer.com/article/10.1186/s13046-019-1353-2

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http://link.springer.com/article/10.1186/s13046-019-1353-2

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