Novel pedigree analysis implicates DNA repair and chromatin remodeling in multiple myeloma risk.

Novel pedigree analysis implicates DNA repair and chromatin remodeling in multiple myeloma risk.

The high-risk pedigree (HRP) design is an established strategy to discover rare, highly-penetrant, Mendelian-like causal variants. Its success, however, in complex traits has been modest, largely due to challenges of genetic heterogeneity and complex inheritance models. We describe a HRP strategy th...

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Bibliographic Details
Main Authors: Rosalie G Waller, Todd M Darlington, Xiaomu Wei, Michael J Madsen, Alun Thomas, Karen Curtin, Hilary Coon, Venkatesh Rajamanickam, Justin Musinsky, David Jayabalan, Djordje Atanackovic, S Vincent Rajkumar, Shaji Kumar, Susan Slager, Mridu Middha, Perrine Galia, Delphine Demangel, Mohamed Salama, Vijai Joseph, James McKay, Kenneth Offit, Robert J Klein, Steven M Lipkin, Charles Dumontet, Celine M Vachon, Nicola J Camp
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-02-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5794067?pdf=render

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http://europepmc.org/articles/PMC5794067?pdf=render

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