A novel RANKL‐targeted flavonoid glycoside prevents osteoporosis through inhibiting NFATc1 and reactive oxygen species

A novel RANKL‐targeted flavonoid glycoside prevents osteoporosis through inhibiting NFATc1 and reactive oxygen species

Abstract Background and purpose Osteoporosis is characterized by excessive bone resorption due to enhanced osteoclast activation. Stimulation of nuclear factor of activated T cells 1 (NFATc1) and accumulation of reactive oxygen species (ROS) are important mechanisms underlying osteoclastogenesis. Ro...

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Bibliographic Details
Main Authors: Guoju Hong, Zhenqiu Chen, Xiaorui Han, Lin Zhou, Fengxiang Pang, Rishana Wu, Yingshan Shen, Xiaoming He, Zhinan Hong, Ziqi Li, Wei He, Qiushi Wei
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:Clinical and Translational Medicine
Subjects:
NFAcT1
osteoclast
osteoporosis
RANKL
Robinin
ROS
Online Access:https://doi.org/10.1002/ctm2.392

Internet

https://doi.org/10.1002/ctm2.392

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