Detection of SRSF2-P95 mutation by high-resolution melting curve analysis and its effect on prognosis in myelodysplastic syndrome.

Hotspot mutations of serine/arginine-rich splicing factor 2 (SRSF2) gene have been identified in a proportion of hematologic malignancies including myelodysplastic syndrome (MDS). The aim of the present study was to develop a new approach to screen SRSF2 mutation and analyze the clinical relevance o...

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Bibliographic Details
Main Authors: Jiang Lin, Jing Yang, Xiang-Mei Wen, Lei Yang, Zhao-Qun Deng, Zhen Qian, Ji-Chun Ma, Hong Guo, Ying-Ying Zhang, Wei Qian, Jun Qian
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4277410?pdf=render