Neuroprotective effect of S-allyl-l-cysteine derivatives against endoplasmic reticulum stress-induced cytotoxicity is independent of calpain inhibition

Neuroprotective effect of S-allyl-l-cysteine derivatives against endoplasmic reticulum stress-induced cytotoxicity is independent of calpain inhibition

S-allyl-l-cysteine (SAC) is known to have neuroprotective properties. We synthesized various SAC derivatives and tested their effects on endoplasmic reticulum stress-induced neurotoxicity in cultured hippocampal neurons (HPNs). Among the compounds tested, S-propyl-l-cysteine (SPC) exhibited the stro...

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Bibliographic Details
Main Authors: Toru Imai, Yasuhiro Kosuge, Hiroaki Saito, Taketo Uchiyama, Taira Wada, Shigeki Shimba, Kumiko Ishige, Shinichi Miyairi, Makoto Makishima, Yoshihisa Ito
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Journal of Pharmacological Sciences
Subjects:
S-allyl-l-cysteine derivatives
Endoplasmic reticulum stress
Hippocampal neuron
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861316000396

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http://www.sciencedirect.com/science/article/pii/S1347861316000396

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