Peripheral cannabinoid-1 receptor blockade restores hypothalamic leptin signaling

Peripheral cannabinoid-1 receptor blockade restores hypothalamic leptin signaling

Objective: In visceral obesity, an overactive endocannabinoid/CB1 receptor (CB1R) system promotes increased caloric intake and decreases energy expenditure, which are mitigated by global or peripheral CB1R blockade. In mice with diet-induced obesity (DIO), inhibition of food intake by the peripheral...

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Bibliographic Details
Main Authors: Joseph Tam, Gergő Szanda, Adi Drori, Ziyi Liu, Resat Cinar, Yoshihiro Kashiwaya, Marc L. Reitman, George Kunos
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Molecular Metabolism
Subjects:
Peripheral CB1 blockade
Leptin resistance
POMC
NPY
Diet-induced obesity
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877817303277

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http://www.sciencedirect.com/science/article/pii/S2212877817303277

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