Interleukin-33-Enhanced CXCR4 Signaling Circuit Mediated by Carcinoma-Associated Fibroblasts Promotes Invasiveness of Head and Neck Cancer

Interleukin-33-Enhanced CXCR4 Signaling Circuit Mediated by Carcinoma-Associated Fibroblasts Promotes Invasiveness of Head and Neck Cancer

Despite recent advances, treatment for head and neck squamous cell carcinoma (HNSCC) has limited efficacy in preventing tumor progression. We confirmed previously that carcinoma-associated fibroblasts (CAF)-induced interleukin-33 (IL-33) contributed to cancer progression. However, the molecular mech...

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Bibliographic Details
Main Authors: Yu-Chun Lin, Wen-Yen Huang, Tsai-Yu Lee, Yi-Ming Chang, Su-Feng Chen, Yaoh-Shiang Lin, Shin Nieh
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
head and neck squamous cell carcinoma
carcinoma-associated fibroblast
interleukin-33/CXCR4 regulatory circuit
tumor microenvironment
tumor progression
Online Access:https://www.mdpi.com/2072-6694/13/14/3442

Internet

https://www.mdpi.com/2072-6694/13/14/3442

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