RNF8-independent Lys63 poly-ubiquitylation prevents genomic instability in response to replication-associated DNA damage.

RNF8-independent Lys63 poly-ubiquitylation prevents genomic instability in response to replication-associated DNA damage.

The cellular response to DNA double strand breaks (DSBs) involves the ordered assembly of repair proteins at or near sites of damage. This process is mediated through post-translational protein modifications that include both phosphorylation and ubiquitylation. Recent data have demonstrated that rec...

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Bibliographic Details
Main Authors: Chantal H M A Ramaekers, Twan van den Beucken, Robert G Bristow, Roland K Chiu, Daniel Durocher, Bradly G Wouters
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3938561?pdf=render

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http://europepmc.org/articles/PMC3938561?pdf=render

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