Metformin Targets Foxo1 to Control Glucose Homeostasis

Metformin Targets Foxo1 to Control Glucose Homeostasis

Metformin is the first-line pharmacotherapy for type 2 diabetes mellitus (T2D). Metformin exerts its glucose-lowering effect primarily through decreasing hepatic glucose production (HGP). However, the precise molecular mechanisms of metformin remain unclear due to supra-pharmacological concentration...

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Bibliographic Details
Main Authors: Xiaoqin Guo, Xiaopeng Li, Wanbao Yang, Wang Liao, James Zheng Shen, Weiqi Ai, Quan Pan, Yuxiang Sun, Kebin Zhang, Rui Zhang, Yuyang Qiu, Qian Dai, Hongting Zheng, Shaodong Guo
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Biomolecules
Subjects:
metformin
salicylate
Foxo1-S273 phosphorylation
type 2 diabetes
glucose homeostasis
Online Access:https://www.mdpi.com/2218-273X/11/6/873

Internet

https://www.mdpi.com/2218-273X/11/6/873

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