Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington's disease

Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington's disease

Huntington's disease (HD) is an inherited progressive neurodegenerative disorder resulting from CAG repeat expansion in the gene that encodes for the protein huntingtin. To identify neuroprotective compound (s) that can slow down disease progression and can be administered long term with few si...

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Bibliographic Details
Main Authors: Wenzhen Duan, Qi Peng, Naoki Masuda, Eric Ford, Erik Tryggestad, Bruce Ladenheim, Ming Zhao, Jean Lud Cadet, John Wong, Christopher A. Ross
Format: Article
Language:English
Published: Elsevier 2008-06-01
Series:Neurobiology of Disease
Subjects:
SSRI
Serotonin
BDNF
Huntington's disease
Neurogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108000259

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http://www.sciencedirect.com/science/article/pii/S0969996108000259

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