In Silico Discovery of Aminoacyl-tRNA Synthetase Inhibitors

Aminoacyl-tRNA synthetases (aaRSs) are enzymes that catalyze the transfer of amino acids to their cognate tRNA. They play a pivotal role in protein synthesis and are essential for cell growth and survival. The aaRSs are one of the leading targets for development of antibiotic agents. In this review,...

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Main Authors:	Yaxue Zhao, Qingqing Meng, Linquan Bai, Huchen Zhou
Format:	Article
Language:	English
Published:	MDPI AG 2014-01-01
Series:	International Journal of Molecular Sciences
Subjects:	aminoacyl-tRNA synthetase inhibitor antibiotics virtual screening structure-based drug design docking
Online Access:	http://www.mdpi.com/1422-0067/15/1/1358

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spelling	doaj-566b6c39a6c4481e99c17ed4d2bde6552020-11-25T00:49:06ZengMDPI AGInternational Journal of Molecular Sciences1422-00672014-01-011511358137310.3390/ijms15011358ijms15011358In Silico Discovery of Aminoacyl-tRNA Synthetase InhibitorsYaxue Zhao0Qingqing Meng1Linquan Bai2Huchen Zhou3School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, ChinaSchool of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, ChinaState Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, ChinaSchool of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, ChinaAminoacyl-tRNA synthetases (aaRSs) are enzymes that catalyze the transfer of amino acids to their cognate tRNA. They play a pivotal role in protein synthesis and are essential for cell growth and survival. The aaRSs are one of the leading targets for development of antibiotic agents. In this review, we mainly focused on aaRS inhibitor discovery and development using in silico methods including virtual screening and structure-based drug design. These computational methods are relatively fast and cheap, and are proving to be of great benefit for the rational development of more potent aaRS inhibitors and other pharmaceutical agents that may usher in a much needed generation of new antibiotics.http://www.mdpi.com/1422-0067/15/1/1358aminoacyl-tRNA synthetaseinhibitorantibioticsvirtual screeningstructure-based drug designdocking
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yaxue Zhao Qingqing Meng Linquan Bai Huchen Zhou
spellingShingle	Yaxue Zhao Qingqing Meng Linquan Bai Huchen Zhou In Silico Discovery of Aminoacyl-tRNA Synthetase Inhibitors International Journal of Molecular Sciences aminoacyl-tRNA synthetase inhibitor antibiotics virtual screening structure-based drug design docking
author_facet	Yaxue Zhao Qingqing Meng Linquan Bai Huchen Zhou
author_sort	Yaxue Zhao
title	In Silico Discovery of Aminoacyl-tRNA Synthetase Inhibitors
title_short	In Silico Discovery of Aminoacyl-tRNA Synthetase Inhibitors
title_full	In Silico Discovery of Aminoacyl-tRNA Synthetase Inhibitors
title_fullStr	In Silico Discovery of Aminoacyl-tRNA Synthetase Inhibitors
title_full_unstemmed	In Silico Discovery of Aminoacyl-tRNA Synthetase Inhibitors
title_sort	in silico discovery of aminoacyl-trna synthetase inhibitors
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1422-0067
publishDate	2014-01-01
description	Aminoacyl-tRNA synthetases (aaRSs) are enzymes that catalyze the transfer of amino acids to their cognate tRNA. They play a pivotal role in protein synthesis and are essential for cell growth and survival. The aaRSs are one of the leading targets for development of antibiotic agents. In this review, we mainly focused on aaRS inhibitor discovery and development using in silico methods including virtual screening and structure-based drug design. These computational methods are relatively fast and cheap, and are proving to be of great benefit for the rational development of more potent aaRS inhibitors and other pharmaceutical agents that may usher in a much needed generation of new antibiotics.
topic	aminoacyl-tRNA synthetase inhibitor antibiotics virtual screening structure-based drug design docking
url	http://www.mdpi.com/1422-0067/15/1/1358
work_keys_str_mv	AT yaxuezhao insilicodiscoveryofaminoacyltrnasynthetaseinhibitors AT qingqingmeng insilicodiscoveryofaminoacyltrnasynthetaseinhibitors AT linquanbai insilicodiscoveryofaminoacyltrnasynthetaseinhibitors AT huchenzhou insilicodiscoveryofaminoacyltrnasynthetaseinhibitors
_version_	1725253014103523328

In Silico Discovery of Aminoacyl-tRNA Synthetase Inhibitors

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