In Silico Discovery of Aminoacyl-tRNA Synthetase Inhibitors

In Silico Discovery of Aminoacyl-tRNA Synthetase Inhibitors

Aminoacyl-tRNA synthetases (aaRSs) are enzymes that catalyze the transfer of amino acids to their cognate tRNA. They play a pivotal role in protein synthesis and are essential for cell growth and survival. The aaRSs are one of the leading targets for development of antibiotic agents. In this review,...

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Bibliographic Details
Main Authors: Yaxue Zhao, Qingqing Meng, Linquan Bai, Huchen Zhou
Format: Article
Language:English
Published: MDPI AG 2014-01-01
Series:International Journal of Molecular Sciences
Subjects:
aminoacyl-tRNA synthetase
inhibitor
antibiotics
virtual screening
structure-based drug design
docking
Online Access:http://www.mdpi.com/1422-0067/15/1/1358

Internet

http://www.mdpi.com/1422-0067/15/1/1358

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