Next-Generation Manufacturing Protocols Enriching TSCM CAR T Cells Can Overcome Disease-Specific T Cell Defects in Cancer Patients

Next-Generation Manufacturing Protocols Enriching TSCM CAR T Cells Can Overcome Disease-Specific T Cell Defects in Cancer Patients

Chimeric antigen receptor (CAR) T cell expansion and persistence emerged as key efficacy determinants in cancer patients. These features are typical of early-memory T cells, which can be enriched with specific manufacturing procedures, providing signal one and signal two in the proper steric conform...

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Bibliographic Details
Main Authors: Silvia Arcangeli, Laura Falcone, Barbara Camisa, Federica De Girardi, Marta Biondi, Fabio Giglio, Fabio Ciceri, Chiara Bonini, Attilio Bondanza, Monica Casucci
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
CAR T
CAR T cell manufacturing
CAR T cell fitness
CAR design
patient samples
B-ALL and PDAC
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01217/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01217/full

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