HMGB1 Protein Interactions in Prostate and Ovary Cancer Models Reveal Links to RNA Processing and Ribosome Biogenesis through NuRD, THOC and Septin Complexes

HMGB1 Protein Interactions in Prostate and Ovary Cancer Models Reveal Links to RNA Processing and Ribosome Biogenesis through NuRD, THOC and Septin Complexes

This study reports the HMGB1 interactomes in prostate and ovary cancer cells lines. Affinity purification coupled to mass spectrometry confirmed that the HMGB1 nuclear interactome is involved in HMGB1 known functions such as maintenance of chromatin stability and regulation of transcription, and als...

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Bibliographic Details
Main Authors: Aida Barreiro-Alonso, Mónica Lamas-Maceiras, Lidia Lorenzo-Catoira, Mercedes Pardo, Lu Yu, Jyoti S. Choudhary, M. Esperanza Cerdán
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cancers
Subjects:
HMGB1 interactome
ribosome biogenesis
RNA processing
ovary cancer
prostate cancer
Online Access:https://www.mdpi.com/2072-6694/13/18/4686

Internet

https://www.mdpi.com/2072-6694/13/18/4686

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