Global Decrease of Histone H3K27 Acetylation in ZEB1-Induced Epithelial to Mesenchymal Transition in Lung Cancer Cells

Global Decrease of Histone H3K27 Acetylation in ZEB1-Induced Epithelial to Mesenchymal Transition in Lung Cancer Cells

The epithelial to mesenchymal transition (EMT) enables epithelial cells with a migratory mesenchymal phenotype. It is activated in cancer cells and is involved in invasion, metastasis and stem-like properties. ZEB1, an E-box binding transcription factor, is a major suppressor of epithelial genes in...

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Bibliographic Details
Main Authors: Slimane Ait-Si-Ali, Joëlle Guilhot, Christopher Korch, Julien Pontis, Robert Gemmill, Aleksander Baldys, Patrick Nasarre, Joëlle Roche, Harry Drabkin
Format: Article
Language:English
Published: MDPI AG 2013-04-01
Series:Cancers
Subjects:
EMT
ZEB1
lung cancer
histone acetylation
RAB25
Online Access:http://www.mdpi.com/2072-6694/5/2/334

Internet

http://www.mdpi.com/2072-6694/5/2/334

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