Targeting the p53 Pathway in CLL: State of the Art and Future Perspectives

The p53 pathway is a desirable therapeutic target, owing to its critical role in the maintenance of genome integrity. This is exemplified in chronic lymphocytic leukemia (CLL), one of the most common adult hematologic malignancies, in which functional loss of p53 arising from genomic aberrations are...

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Bibliographic Details
Main Authors: Marwan Kwok, Angelo Agathanggelou, Nicholas Davies, Tatjana Stankovic
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cancers
Subjects:
p53
ATM
CDK
ATR
Online Access:https://www.mdpi.com/2072-6694/13/18/4681