Germinal center hypoxia in tumor-draining lymph nodes negatively regulates tumor-induced humoral immune responses in mouse models of breast cancer

Germinal center hypoxia in tumor-draining lymph nodes negatively regulates tumor-induced humoral immune responses in mouse models of breast cancer

Hypoxia develops in germinal centers (GCs) induced by model antigens; however, it is unknown whether tumor-reactive GCs are also hypoxic. We identified GC hypoxia in lymph nodes (LNs) draining murine mammary tumors and lethally irradiated tumor cells, and found that hypoxia is associated with the le...

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Bibliographic Details
Main Authors: Natalie S Firmino, Rachel A Cederberg, Che-Min Lee, Rocky Shi, Brennan J Wadsworth, S Elizabeth Franks, Kiersten N Thomas, Lisa R Decotret, Kevin L Bennewith
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:OncoImmunology
Subjects:
b cells
germinal centers
hypoxia
breast cancer
lymph nodes
Online Access:http://dx.doi.org/10.1080/2162402X.2021.1959978

Internet

http://dx.doi.org/10.1080/2162402X.2021.1959978

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