Assessment of in vivo and in vitro genotoxicity of glibenclamide in eukaryotic cells.

Glibenclamide is an oral hypoglycemic drug commonly prescribed for the treatment of type 2 diabetes mellitus, whose anti-tumor activity has been recently described in several human cancer cells. The mutagenic potential of such an antidiabetic drug and its recombinogenic activity in eukaryotic cells...

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Bibliographic Details
Main Authors: Juliane Rocha de Sant'Anna, Claudinéia Conationi da Silva Franco, Paulo Cezar de Freitas Mathias, Marialba Avezum Alves de Castro-Prado
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4372363?pdf=render