Spatiotemporal Developmental Upregulation of Prestin Correlates With the Severity and Location of Cyclodextrin-Induced Outer Hair Cell Loss and Hearing Loss

Spatiotemporal Developmental Upregulation of Prestin Correlates With the Severity and Location of Cyclodextrin-Induced Outer Hair Cell Loss and Hearing Loss

2-Hyroxypropyl-beta-cyclodextrin (HPβCD) is being used to treat Niemann-Pick C1, a fatal neurodegenerative disease caused by abnormal cholesterol metabolism. HPβCD slows disease progression, but unfortunately causes severe, rapid onset hearing loss by destroying the outer hair cells (OHC). HPβCD-ind...

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Bibliographic Details
Main Authors: Dalian Ding, Haiyan Jiang, Senthilvelan Manohar, Xiaopeng Liu, Li Li, Guang-Di Chen, Richard Salvi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cyclodextrin
prestin
Niemann-Pick C1
spiral ganglion neurons
outer hair cells
inner hair cells
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.643709/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.643709/full

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