The Role of NADPH oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts

The Role of NADPH oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts

Chronic liver injury, resulted from different etiologies (e.g. virus infection, alcohol abuse, nonalcoholic steatohepatitis (NASH) and cholestasis) can lead to liver fibrosis characterized by the excess accumulation of extracellular matrix (ECM) proteins (e.g. type I collagen). Hepatic myofibroblast...

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Bibliographic Details
Main Authors: Shuang eLiang, Tatiana eKisseleva, David eBrenner
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Physiology
Subjects:
Myofibroblasts
NADPH Oxidase
liver fibrosis
reactive oxygen species (ROS)
Hepatic stellate cells (HSCs)
Hepatocytes.
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00017/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00017/full

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