A small molecule inhibitor of ETV1, YK-4-279, prevents prostate cancer growth and metastasis in a mouse xenograft model.

A small molecule inhibitor of ETV1, YK-4-279, prevents prostate cancer growth and metastasis in a mouse xenograft model.

The erythroblastosis virus E26 transforming sequences (ETS) family of transcription factors consists of a highly conserved group of genes that play important roles in cellular proliferation, differentiation, migration and invasion. Chromosomal translocations fusing ETS factors to promoters of androg...

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Bibliographic Details
Main Authors: Said Rahim, Tsion Minas, Sung-Hyeok Hong, Sarah Justvig, Haydar Çelik, Yasemin Saygideger Kont, Jenny Han, Abraham T Kallarakal, Yali Kong, Michelle A Rudek, Milton L Brown, Bhaskar Kallakury, Jeffrey A Toretsky, Aykut Üren
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4257561?pdf=render

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http://europepmc.org/articles/PMC4257561?pdf=render

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