Trans-ethnic variation in germline variants of patients with renal cell carcinoma

Trans-ethnic variation in germline variants of patients with renal cell carcinoma

Summary: Prior studies of the renal cell carcinoma (RCC) germline landscape investigated predominantly patients of European ancestry. We examine the frequency of germline pathogenic and likely pathogenic (P/LP) variants in 1,829 patients with RCC from various ancestries. Overall, P/LP variants are f...

Full description

Bibliographic Details
Main Authors: Sarah Abou Alaiwi, Amin H. Nassar, Elio Adib, Stefan M. Groha, Elie W. Akl, Bradley A. McGregor, Edward D. Esplin, Shan Yang, Kathryn Hatchell, Vincent Fusaro, Sarah Nielsen, David J. Kwiatkowski, Guru P. Sonpavde, Mark Pomerantz, Judy E. Garber, Matthew L. Freedman, Huma Q. Rana, Alexander Gusev, Toni K. Choueiri
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Cell Reports
Subjects:
renal cell carcinoma
kidney cancer
germline variants
DNA damage repair
clinical genetics
Ancestry
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721002400

Internet

http://www.sciencedirect.com/science/article/pii/S2211124721002400

Similar Items