IPS-1 is essential for the control of West Nile virus infection and immunity.

IPS-1 is essential for the control of West Nile virus infection and immunity.

The innate immune response is essential for controlling West Nile virus (WNV) infection but how this response is propagated and regulates adaptive immunity in vivo are not defined. Herein, we show that IPS-1, the central adaptor protein to RIG-I-like receptor (RLR) signaling, is essential for trigge...

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Bibliographic Details
Main Authors: Mehul S Suthar, Daphne Y Ma, Sunil Thomas, Jennifer M Lund, Nu Zhang, Stephane Daffis, Alexander Y Rudensky, Michael J Bevan, Edward A Clark, Murali-Krishna Kaja, Michael S Diamond, Michael Gale
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-02-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2816698?pdf=render

Internet

http://europepmc.org/articles/PMC2816698?pdf=render

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