The Role of Sartans in the Treatment of Stroke and Subarachnoid Hemorrhage: A Narrative Review of Preclinical and Clinical Studies

The Role of Sartans in the Treatment of Stroke and Subarachnoid Hemorrhage: A Narrative Review of Preclinical and Clinical Studies

<i>Background</i>: Delayed cerebral vasospasm (DCVS) due to aneurysmal subarachnoid hemorrhage (aSAH) and its sequela, delayed cerebral ischemia (DCI), are associated with poor functional outcome. Endothelin-1 (ET-1) is known to play a major role in mediating cerebral vasoconstriction. A...

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Bibliographic Details
Main Authors: Stefan Wanderer, Basil E. Grüter, Fabio Strange, Sivani Sivanrupan, Stefano Di Santo, Hans Rudolf Widmer, Javier Fandino, Serge Marbacher, Lukas Andereggen
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Brain Sciences
Subjects:
aneurysmal subarachnoid hemorrhage
delayed cerebral vasospasm
ischemic stroke
sartans
therapeutic interventions
Online Access:https://www.mdpi.com/2076-3425/10/3/153

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https://www.mdpi.com/2076-3425/10/3/153

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