The Anti-inflammatory Compound Candesartan Cilexetil Improves Neurological Outcomes in a Mouse Model of Neonatal Hypoxia

The Anti-inflammatory Compound Candesartan Cilexetil Improves Neurological Outcomes in a Mouse Model of Neonatal Hypoxia

Recent studies suggest that mild hypoxia-induced neonatal seizures can trigger an acute neuroinflammatory response leading to long-lasting changes in brain excitability along with associated cognitive and behavioral deficits. The cellular elements and signaling pathways underlying neuroinflammation...

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Bibliographic Details
Main Authors: Sean Quinlan, Paula Merino-Serrais, Alessandra Di Grande, Heiko Dussmann, Jochen H. M. Prehn, Tríona Ní Chonghaile, David C. Henshall, Eva M. Jimenez-Mateos
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
neonatal encephalopathy
inflammation
microglia
seizures
hypoxia
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01752/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01752/full

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