Discovery of novel helix binding sites at protein-protein interfaces

Protein-protein interactions (PPIs) play a key role in numerous biological processes. Many efforts have been undertaken to develop PPI modulators for therapeutic applications; however, to date, most of the peptide binders designed to target PPIs are derived from native binding helices or using the n...

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Bibliographic Details
Main Authors: Wei Yang, Xiangyu Sun, Changsheng Zhang, Luhua Lai
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Computational and Structural Biotechnology Journal
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037019302053