Identifying human disease genes through cross-species gene mapping of evolutionary conserved processes.

Understanding complex networks that modulate development in humans is hampered by genetic and phenotypic heterogeneity within and between populations. Here we present a method that exploits natural variation in highly diverse mouse genetic reference panels in which genetic and environmental factors...

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Bibliographic Details
Main Authors: Martin Poot, Alexandra Badea, Robert W Williams, Martien J Kas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3087714?pdf=render