Altered intrinsic excitability of hippocampal CA1 pyramidal neurons in aged PDAPP mice

Altered intrinsic excitability of hippocampal CA1 pyramidal neurons in aged PDAPP mice

Amyloidopathy involves the accumulation of insoluble amyloid β (Aβ) species in the brain’s parenchyma and is a key histopathological hallmark of Alzheimer’s disease (AD). Work on transgenic mice that overexpress A suggests that elevated A levels in the brain are associated with aberrant epileptifo...

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Bibliographic Details
Main Authors: Francesco eTamagnini, Janet eNovelia, Talitha L Kerrigan, Jon T Brown, Krasimira eTsaneva-Atanasova, Andrew D Randall
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Hippocampus
Ageing
hyperexcitability
Capacitance
Membrane properties
firing frequency
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00372/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00372/full

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