Reexamination of N-terminal domains of syntaxin-1 in vesicle fusion from central murine synapses

Reexamination of N-terminal domains of syntaxin-1 in vesicle fusion from central murine synapses

Syntaxin-1 (STX1) and Munc18-1 are two requisite components of synaptic vesicular release machinery, so much so synaptic transmission cannot proceed in their absence. They form a tight complex through two major binding modes: through STX1’s N-peptide and through STX1’s closed conformation driven by...

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Bibliographic Details
Main Authors: Gülçin Vardar, Andrea Salazar-Lázaro, Marisa Brockmann, Marion Weber-Boyvat, Sina Zobel, Victor Wumbor-Apin Kumbol, Thorsten Trimbuch, Christian Rosenmund
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-08-01
Series:eLife
Subjects:
syntaxin-1
Munc18-1
N-peptide
habc-domain
leopen conformation
synaptic transmission
Online Access:https://elifesciences.org/articles/69498

Internet

https://elifesciences.org/articles/69498

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