Biochemical patterns of antibody polyreactivity revealed through a bioinformatics-based analysis of CDR loops

Biochemical patterns of antibody polyreactivity revealed through a bioinformatics-based analysis of CDR loops

Antibodies are critical components of adaptive immunity, binding with high affinity to pathogenic epitopes. Antibodies undergo rigorous selection to achieve this high affinity, yet some maintain an additional basal level of low affinity, broad reactivity to diverse epitopes, a phenomenon termed ‘pol...

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Bibliographic Details
Main Authors: Christopher T Boughter, Marta T Borowska, Jenna J Guthmiller, Albert Bendelac, Patrick C Wilson, Benoit Roux, Erin J Adams
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-11-01
Series:eLife
Subjects:
biophysics
antibody specificity
information theory
machine learning
bioinformatics
immunology
Online Access:https://elifesciences.org/articles/61393

Internet

https://elifesciences.org/articles/61393

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