Targeting B7-H3 via chimeric antigen receptor T cells and bispecific killer cell engagers augments antitumor response of cytotoxic lymphocytes

Targeting B7-H3 via chimeric antigen receptor T cells and bispecific killer cell engagers augments antitumor response of cytotoxic lymphocytes

Abstract Background B7-H3, an immune-checkpoint molecule and a transmembrane protein, is overexpressed in non-small cell lung cancer (NSCLC), making it an attractive therapeutic target. Here, we aimed to systematically evaluate the value of B7-H3 as a target in NSCLC via T cells expressing B7-H3-spe...

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Bibliographic Details
Main Authors: Jie Liu, Shuo Yang, Bihui Cao, Guangyu Zhou, Fengjuan Zhang, Yuan Wang, Rixin Wang, Lipeng Zhu, Ya Meng, Cong Hu, Hui Liang, Xu Lin, Kangshun Zhu, Guokai Chen, Kathy Qian Luo, Lijun Di, Qi Zhao
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Hematology & Oncology
Subjects:
B7-H3
Chimeric antigen receptor
Bispecific antibody
Non-small cell lung cancer
PD-L1
BiKE
Online Access:https://doi.org/10.1186/s13045-020-01024-8

Internet

https://doi.org/10.1186/s13045-020-01024-8

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