Semi-synthesis of β-keto-1,2,3-triazole derivatives from ethinylestradiol and evaluation of the cytotoxic activity

Semi-synthesis of β-keto-1,2,3-triazole derivatives from ethinylestradiol and evaluation of the cytotoxic activity

In this study, we report our contribution to the application of the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction for the synthesis of β-keto-1,2,3-triazole derivatives 3a-f from ethinylestradiol and their application in the inhibition of two human cancer cells lines: human breast ade...

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Bibliographic Details
Main Authors: Thayane M. Queiroz, Erika V.M. Orozco, Valdenizia R. Silva, Luciano S. Santos, Milena B.P. Soares, Daniel P. Bezerra, André L.M. Porto
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Heliyon
Subjects:
Organic chemistry
Pharmaceutical chemistry
Toxicology
β-keto-1,2,3-triazoles
Ethinylestradiol
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Online Access:http://www.sciencedirect.com/science/article/pii/S2405844019360682

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http://www.sciencedirect.com/science/article/pii/S2405844019360682

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