Cytosine methylation of mature microRNAs inhibits their functions and is associated with poor prognosis in glioblastoma multiforme

Cytosine methylation of mature microRNAs inhibits their functions and is associated with poor prognosis in glioblastoma multiforme

Abstract Background Literature reports that mature microRNA (miRNA) can be methylated at adenosine, guanosine and cytosine. However, the molecular mechanisms involved in cytosine methylation of miRNAs have not yet been fully elucidated. Here we investigated the biological role and underlying mechani...

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Bibliographic Details
Main Authors: Mathilde Cheray, Amandine Etcheverry, Camille Jacques, Romain Pacaud, Gwenola Bougras-Cartron, Marc Aubry, Florent Denoual, Pierre Peterlongo, Arulraj Nadaradjane, Joséphine Briand, Farida Akcha, Dominique Heymann, François M. Vallette, Jean Mosser, Benjamin Ory, Pierre-François Cartron
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Molecular Cancer
Subjects:
miRNA
Cytosine-methylation
Epigenetics
DNMT3A
AGO4
Glioblastoma
Online Access:http://link.springer.com/article/10.1186/s12943-020-01155-z

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http://link.springer.com/article/10.1186/s12943-020-01155-z

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