Distinct Bacterial Pathways Influence the Efficacy of Antibiotics against Mycobacterium tuberculosis

Distinct Bacterial Pathways Influence the Efficacy of Antibiotics against Mycobacterium tuberculosis

Understanding how Mycobacterium tuberculosis survives during antibiotic treatment is necessary to rationally devise more effective tuberculosis (TB) chemotherapy regimens. Using genome-wide mutant fitness profiling and the mouse model of TB, we identified genes that alter antibiotic efficacy specifi...

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Bibliographic Details
Main Authors: Michelle M. Bellerose, Megan K. Proulx, Clare M. Smith, Richard E. Baker, Thomas R. Ioerger, Christopher M. Sassetti
Format: Article
Language:English
Published: American Society for Microbiology 2020-08-01
Series:mSystems
Subjects:
antibiotic treatment
host-microbe interactions
microbial genomics
mycobacterium tuberculosis
Online Access:https://doi.org/10.1128/mSystems.00396-20

Internet

https://doi.org/10.1128/mSystems.00396-20

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