Schizosaccharomyces pombe MutSα and MutLα Maintain Stability of Tetra-Nucleotide Repeats and Msh3 of Hepta-Nucleotide Repeats

Schizosaccharomyces pombe MutSα and MutLα Maintain Stability of Tetra-Nucleotide Repeats and Msh3 of Hepta-Nucleotide Repeats

Defective mismatch repair (MMR) in humans is associated with colon cancer and instability of microsatellites, that is, DNA sequences with one or several nucleotides repeated. Key factors of eukaryotic MMR are the heterodimers MutSα (Msh2-Msh6), which recognizes base-base mismatches and unpaired nucl...

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Bibliographic Details
Main Authors: Desirée Villahermosa, Olaf Christensen, Karen Knapp, Oliver Fleck
Format: Article
Language:English
Published: Oxford University Press 2017-05-01
Series:G3: Genes, Genomes, Genetics
Subjects:
mismatch repair
microsatellite instability
homologous recombination repair
repetitive DNA
FEN1
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.117.040816

Internet

http://g3journal.org/lookup/doi/10.1534/g3.117.040816

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