Poly- and autoreactivity of HIV-1 bNAbs: implications for vaccine design

Abstract A central puzzle in HIV-1 research is the inability of vaccination or even infection to reliably elicit humoral responses against broadly neutralizing epitopes in the HIV-1 envelope protein. In infected individuals, broadly neutralizing antibodies (bNAbs) do arise in a substantial minority,...

Full description

Bibliographic Details
Main Authors: Joel Finney, Garnett Kelsoe
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Retrovirology
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12977-018-0435-0