Neuroprotective Effect of Ligustilide through Induction of α-Secretase Processing of Both APP and Klotho in a Mouse Model of Alzheimer’s Disease

Neuroprotective Effect of Ligustilide through Induction of α-Secretase Processing of Both APP and Klotho in a Mouse Model of Alzheimer’s Disease

Emerging evidence suggests that alpha-processing single transmembrane proteins, amyloid precursor protein (APP) and anti-aging protein Klotho, are likely to be involved in the progression of Alzheimer’s disease (AD). The natural phthalide Ligustilide (LIG) has been demonstrated to protect against ag...

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Bibliographic Details
Main Authors: Xi Kuang, Hong-Jing Zhou, Amy H. Thorne, Xi-Nan Chen, Lin-Jiao Li, Jun-Rong Du
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Aging Neuroscience
Subjects:
Ligustilide (LIG)
Klotho
APP
α-secretase processing
β-amyloid
Online Access:http://journal.frontiersin.org/article/10.3389/fnagi.2017.00353/full

Internet

http://journal.frontiersin.org/article/10.3389/fnagi.2017.00353/full

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