Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy

Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy

Altered lipid metabolism has been associated with tumour malignancy, but underlying mechanisms are not clear. Here the authors show that proto-oncogene Src interacts and phosphorylates metabolic enzyme phosphatidic acid phosphatase LPIN1 (lipin-1) to promote growth and metastasis in breast cancer.

Bibliographic Details
Main Authors: Lintao Song, Zhihua Liu, Hui-Hui Hu, Ying Yang, Terytty Yang Li, Zhi-Zhong Lin, Jing Ye, Jianing Chen, Xi Huang, Dong-Tai Liu, Jing Zhou, Yiran Shi, Hao Zhao, Changchuan Xie, Lanfen Chen, Erwei Song, Shu-Yong Lin, Sheng-Cai Lin
Format: Article
Language:English
Published: Nature Publishing Group 2020-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19694-w

Internet

https://doi.org/10.1038/s41467-020-19694-w

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