Genetic deletion of mGlu2 metabotropic glutamate receptors improves the short-term outcome of cerebral transient focal ischemia

Genetic deletion of mGlu2 metabotropic glutamate receptors improves the short-term outcome of cerebral transient focal ischemia

Abstract We have recently shown that pharmacological blockade of mGlu2 metabotropic glutamate receptors protects vulnerable neurons in the 4-vessel occlusion model of transient global ischemia, whereas receptor activation amplifies neuronal death. This raised the possibility that endogenous activati...

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Bibliographic Details
Main Authors: Federica Mastroiacovo, Slavianka Moyanova, Milena Cannella, Anderson Gaglione, Remy Verhaeghe, Giovanna Bozza, Michele Madonna, Marta Motolese, Anna Traficante, Barbara Riozzi, Valeria Bruno, Giuseppe Battaglia, David Lodge, Ferdinando Nicoletti
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Molecular Brain
Subjects:
Focal ischemia
mGlu2 receptor
Genetic deletion
Neuroprotection
Neurological score
Online Access:http://link.springer.com/article/10.1186/s13041-017-0319-6

Internet

http://link.springer.com/article/10.1186/s13041-017-0319-6

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