Mitochondrial Delivery of Phenol Substructure Triggers Mitochondrial Depolarization and Apoptosis of Cancer Cells

Mitochondrial Delivery of Phenol Substructure Triggers Mitochondrial Depolarization and Apoptosis of Cancer Cells

Antitumor chemotherapy remains one of the most important challenge of the medicinal chemistry. Emerging research in chemotherapy is focused on exploiting the biochemical differences between cancer cell and normal cell metabolism in order to reduce the side effects and increase antitumor therapy effi...

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Bibliographic Details
Main Authors: Elena Gazzano, Loretta Lazzarato, Barbara Rolando, Joanna Kopecka, Stefano Guglielmo, Costanzo Costamagna, Konstantin Chegaev, Chiara Riganti
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Pharmacology
Subjects:
triphenylphosphonium cation
phenols
cancer mitochondrial biogenesis
cancer mitochondrial energy metabolism
mitochondrial-dependent apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00580/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00580/full

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