A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice

A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice

Risk for Atrial Fibrillation (AF), the most common human arrhythmia, has a major genetic component. The T-box transcription factor TBX5 influences human AF risk, and adult-specific Tbx5-mutant mice demonstrate spontaneous AF. We report that TBX5 is critical for cellular Ca2+ homeostasis, providing a...

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Bibliographic Details
Main Authors: Wenli Dai, Brigitte Laforest, Leonid Tyan, Kaitlyn M Shen, Rangarajan D Nadadur, Francisco J Alvarado, Stefan R Mazurek, Sonja Lazarevic, Margaret Gadek, Yitang Wang, Ye Li, Hector H Valdivia, Le Shen, Michael T Broman, Ivan P Moskowitz, Christopher R Weber
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-03-01
Series:eLife
Subjects:
atrial fibrillation
Tbx5
SR calcium ATPase
calcium handling
sodium-calcium exchanger
triggered activity
Online Access:https://elifesciences.org/articles/41814

Internet

https://elifesciences.org/articles/41814

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