FANCJ/BACH1 acetylation at lysine 1249 regulates the DNA damage response.

FANCJ/BACH1 acetylation at lysine 1249 regulates the DNA damage response.

BRCA1 promotes DNA repair through interactions with multiple proteins, including CtIP and FANCJ (also known as BRIP1/BACH1). While CtIP facilitates DNA end resection when de-acetylated, the function of FANCJ in repair processing is less well defined. Here, we report that FANCJ is also acetylated. Pr...

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Bibliographic Details
Main Authors: Jenny Xie, Min Peng, Shawna Guillemette, Steven Quan, Stephanie Maniatis, Yuliang Wu, Aditya Venkatesh, Scott A Shaffer, Robert M Brosh, Sharon B Cantor
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-07-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3390368?pdf=render

Internet

http://europepmc.org/articles/PMC3390368?pdf=render

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