Blockade of TRPM7 Alleviates Chondrocyte Apoptosis and Articular Cartilage Damage in the Adjuvant Arthritis Rat Model Through Regulation of the Indian Hedgehog Signaling Pathway

Blockade of TRPM7 Alleviates Chondrocyte Apoptosis and Articular Cartilage Damage in the Adjuvant Arthritis Rat Model Through Regulation of the Indian Hedgehog Signaling Pathway

Articular cartilage damage with subsequent impairment of joint function is a common feature of articular diseases, in particular, rheumatoid arthritis and osteoarthritis. While articular cartilage injury mediated by chondrocyte apoptosis is a known major pathological feature of arthritis, the specif...

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Bibliographic Details
Main Authors: Ganggang Ma, Yang Yang, Yong Chen, Xin Wei, Jie Ding, Ren-Peng Zhou, Wei Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
arthritis
TRPM7
2-APB
indian hedgehog
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.655551/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.655551/full

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