PACAP signaling exerts opposing effects on neuroprotection and neuroinflammation during disease progression in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis

PACAP signaling exerts opposing effects on neuroprotection and neuroinflammation during disease progression in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic peptide with autocrine neuroprotective and paracrine anti-inflammatory properties in various models of acute neuronal damage and neurodegenerative diseases. Therefore, we examined a possible beneficial role of endogenous PAC...

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Bibliographic Details
Main Authors: Cornelia Ringer, Luisa-Sybille Büning, Martin K.H. Schäfer, Lee E. Eiden, Eberhard Weihe, Burkhard Schütz
Format: Article
Language:English
Published: Elsevier 2013-06-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis
Microglia
Neuroinflammation
Neuroprotection
Neuropeptide
Parasympathetic
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113000727

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http://www.sciencedirect.com/science/article/pii/S0969996113000727

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