SH3BP2 gain-of-function mutation exacerbates inflammation and bone loss in a murine collagen-induced arthritis model.

SH3BP2 gain-of-function mutation exacerbates inflammation and bone loss in a murine collagen-induced arthritis model.

SH3BP2 is a signaling adapter protein which regulates immune and skeletal systems. Gain-of-function mutations in SH3BP2 cause cherubism, characterized by jawbone destruction. This study was aimed to examine the role of SH3BP2 in inflammatory bone loss using a collagen-induced arthritis (CIA) model.C...

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Bibliographic Details
Main Authors: Tomoyuki Mukai, Richard Gallant, Shu Ishida, Teruhito Yoshitaka, Mizuho Kittaka, Keiichiro Nishida, David A Fox, Yoshitaka Morita, Yasuyoshi Ueki
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4140794?pdf=render

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http://europepmc.org/articles/PMC4140794?pdf=render

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