Berberine reduces fibronectin expression by suppressing the S1P-S1P2 receptor pathway in experimental diabetic nephropathy models.

Berberine reduces fibronectin expression by suppressing the S1P-S1P2 receptor pathway in experimental diabetic nephropathy models.

The accumulation of glomerular extracellular matrix (ECM) is one of the critical pathological characteristics of diabetic renal fibrosis. Fibronectin (FN) is an important constituent of ECM. Our previous studies indicate that the activation of the sphingosine kinase 1 (SphK1)-sphingosine 1- phosphat...

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Bibliographic Details
Main Authors: Kaipeng Huang, Weihua Liu, Tian Lan, Xi Xie, Jing Peng, Juan Huang, Shaogui Wang, Xiaoyan Shen, Peiqing Liu, Heqing Huang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22937115/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22937115/?tool=EBI

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